IGF-1 LR3
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IGF-1 LR3
Compounded Injectable — Provider-Directed Dosing Protocol
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analog of IGF-1 engineered with amino acid substitutions that reduce its affinity for binding proteins and extend its half-life. It has been studied for its role in cellular growth signaling, protein synthesis pathways, and tissue repair processes. Treatment decisions are made by licensed providers following a thorough clinical evaluation.
- ✓ Extended half-life analog of IGF-1 — engineered for prolonged receptor engagement
- ✓ Studied for its role in cellular growth signaling and protein synthesis pathways
- ✓ Injectable — provider-directed dosing and administration
- ✓ Compounded in an FDA-registered 503A pharmacy
- ✓ Provider evaluation included — clinical review before every prescription
Intro pricing — locked in for active program participants
- ✓ 4-week supply · dosage set by your provider
- ✓ Bacteriostatic water for reconstitution
- ✓ Syringes & alcohol swabs
- ✓ Free cold-pack shipping
- ✓ Ongoing provider oversight & prescription management
- ✓ Medication fulfilled if prescribed
Your provider may authorize multiple refills as part of your treatment plan. Refills and treatment continuation are determined by your licensed provider.
Treatment decisions are made by licensed medical providers following a clinical review. Results vary and no outcomes are guaranteed.
Start My Evaluation →The IGF-1 receptor mechanism — how researchers are studying it
IGF-1 LR3 engages the same receptor as endogenous IGF-1 but with a modified structure studied for its extended activity profile.
IGF-1 LR3 has been studied for its activity at the IGF-1 receptor (IGF-1R), which plays a role in cellular growth signaling and proliferation pathways. Research has examined how its extended half-life affects receptor engagement duration compared to native IGF-1.
Research has examined IGF-1 LR3’s involvement in protein synthesis signaling pathways. Studies have investigated its role in mTOR and PI3K pathway activation, which are involved in cellular growth and repair processes.
A key structural feature of IGF-1 LR3 is its reduced affinity for IGF binding proteins (IGFBPs) compared to native IGF-1. Research has studied how this characteristic affects its bioavailability and duration of biological activity.
IGF-1 LR3 has been the subject of published research examining its cellular signaling properties. Treatment decisions involving IGF-1 LR3 are made by licensed providers based on individual health evaluations.
How it works
From your first inquiry to an active treatment plan — here’s the process.
Answer a short health questionnaire. Takes under 5 minutes. Fully HIPAA-compliant. Your provider uses this to evaluate candidacy.
A licensed provider reviews your health profile and determines whether this treatment is appropriate for your individual situation — usually same day.
If prescribed, your kit ships from our FDA-registered pharmacy, cold-packed and discreetly packaged. Ships within 24 hours of provider approval.
Your provider sets the dosing schedule. Self-administered at home. Support team available throughout your program.
What’s in your kit
Everything included for your provider-directed protocol. Nothing unnecessary.
Compounded IGF-1 LR3 in your provider-determined dosage, formulated at an FDA-registered 503A pharmacy.
For reconstituting your lyophilized peptide. Included and pre-measured for your kit.
4-week supply of 1mL insulin syringes. Ready to use, no extra equipment needed.
Individually wrapped prep swabs for site sterilization before each injection.
Provider-issued protocol card with injection guidance and dosing schedule specific to your prescription.
Questions? Our support team is available 7 days a week. Treatment program participants get priority response.
Quality Control
Every API tested 5 ways before it touches a vial.
The active pharmaceutical ingredients in your medication are tested at the API level — before compounding — across five independent quality markers.
Confirms you’re getting exactly the dose on the label. No underdosed vials.
Zero microbial contamination. Required for anything injected into the body.
Tests for bacterial byproducts that cause dangerous inflammatory responses.
Ensures the compound is stable and safe at the correct physiological pH.
Verifies there are no foreign substances, degradants, or unknown compounds present.
Member experiences.
Verified participants sharing their experience with the process and their provider-directed program.
“My provider screened my entire metabolic and hormonal panel before approving. That thoroughness — especially for a compound like this — is exactly what I required. Legitimate clinical process from a legitimate platform.”
“The intake was the most comprehensive of any telehealth platform I’ve used. My provider flagged a prior hormonal condition to discuss before starting. That level of clinical responsibility is rare.”
“FDA-registered pharmacy, real provider screening, responsive support. Kit arrived cold-packed with clear instructions. My provider included specific notes based on my intake. Everything as advertised.”
What to expect
Every protocol works on its own timeline. Your provider will set expectations specific to your prescription.
Provider reviews intake carefully. Starting dose is set conservatively based on your health profile.
Provider monitors response and adjusts dosing as needed based on individual clinical status.
Provider reassesses and adjusts the protocol based on your progress and clinical response.
Treatment continuation is determined by your licensed provider based on ongoing clinical evaluation.
Before you begin
A few things to know so you’re set up for a safe, provider-guided experience.
Administer only as directed by your provider. Your provider instructions will include guidance specific to your protocol — do not deviate from the prescribed schedule.
Store your vials refrigerated (36–46°F). Do not freeze. Keep out of direct light. Follow any specific storage instructions included with your kit.
Never mix with other medications in the same syringe. If you experience unexpected side effects, hold your dose and contact your provider before continuing.
Contact your provider or our support team before adjusting your protocol. Never self-escalate dosing without provider authorization.
Individual responses vary. Your provider will set timeline expectations specific to your prescription and health profile. Results are not guaranteed.
Your dosage is determined by your provider after reviewing your intake. You will not know your starting dose until after provider approval.
Is this right for you?
Candidacy is determined by your licensed provider after reviewing your health profile. These are general guidelines — your provider makes the final determination.
✅ May be a candidate if you…
- → Are interested in growth factor research and provider-directed treatment programs
- → Have undergone or are open to a comprehensive licensed provider evaluation
- → Are committed to following a provider-directed protocol
- → Are not pregnant or breastfeeding
- → Have no active or prior malignancy (provider will screen thoroughly)
- → Are in one of our currently served states
❌ Likely not a candidate if you…
- → Are currently pregnant or planning to become pregnant
- → Have an active or history of malignancy — provider screens thoroughly for this
- → Have diabetes or significant insulin resistance not disclosed at intake
- → Are under 18 years of age
- → Are outside our currently served states
- → Are unwilling to complete a comprehensive provider intake evaluation
Member reviews
4.8 out of 5 — based on 78 verified purchases
78 verified reviews
My provider ran through my full hormonal history, prior bloodwork, and current medications before approving. For a compound with this profile, that level of clinical diligence is exactly what I required. Professional across the board.
✓ Verified PurchaseFDA-registered pharmacy, real provider screening including malignancy history, same-day approval, fast cold-packed delivery. This is the standard I expect and HumanPeptide delivered it.
✓ Verified PurchaseI came in knowing the literature. My provider demonstrated they knew it too — not just reviewing boxes but engaging with the science in my specific context. That clinical depth is rare in telehealth.
✓ Verified PurchaseMy provider started me at a more conservative dose than I expected and explained exactly why based on my bloodwork. I appreciated that caution. Two months in and the protocol has been adjusted twice based on my response.
✓ Verified PurchaseFrequently asked questions
Straight answers. No fluff.
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analog of IGF-1 with amino acid modifications that reduce its affinity for binding proteins and extend its half-life compared to native IGF-1. It has been studied for its role in cellular growth signaling, protein synthesis pathways, and tissue repair. Treatment decisions involving IGF-1 LR3 require a thorough provider evaluation and are made by licensed healthcare providers.
IGF-1 LR3 is not FDA-approved. It is available as a compounded medication through licensed providers and FDA-registered 503A compounding pharmacies. Due to its potent growth factor activity, your provider will conduct a thorough clinical evaluation — including screening for any malignancy history — before making a treatment decision.
Yes. This medication requires a prescription from a licensed provider. After completing your intake form, a provider reviews your health profile and determines whether this treatment is appropriate. If approved, the prescription is filled by our compounding pharmacy. No office visit required.
We currently serve: Florida, Rhode Island, Missouri, Wisconsin, Montana, Arizona, Vermont, Virginia, Wyoming, South Dakota, New York, Georgia, and New Mexico. We’re expanding — check back if your state isn’t listed.
Your provider may authorize a multi-month prescription as part of your treatment plan. When a multi-month prescription is issued, your program is billed monthly and medication is fulfilled for each billing period — no new provider approval is required until the prescription expires. Refills and treatment continuation are always determined by your licensed provider.
Cancel anytime before your next billing cycle — no fees, no phone calls. Log into your account and cancel in one click, or contact our support team and we’ll handle it immediately. Cancellation must be submitted at least 72 hours before your billing date.
Potential side effects vary by individual and are reviewed by your provider at intake. Your provider will set expectations and monitoring guidance specific to your protocol. Contact your provider or our support team if you experience unexpected symptoms.
Not at this time. FSA/HSA eligibility is on our roadmap and we’ll notify members when it becomes available.
⚠️ Medical Disclaimer
The information on this page is for educational purposes only and does not constitute medical advice. IGF-1 LR3 is not FDA-approved and is available only through licensed healthcare providers via FDA-registered 503A compounding pharmacies. Treatment decisions are made by licensed medical providers following a clinical review. Results vary and no outcomes are guaranteed. HumanPeptide.com is not a licensed medical provider. Always consult your physician before starting any new medication or treatment protocol. This product has not been evaluated by the FDA for the diagnosis, treatment, cure, or prevention of any disease.
Ready to explore your treatment options?
Complete your intake and a licensed provider will review your profile — usually same day.
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